Citicoline, also known as cytidine diphosphate-choline (CDP-Choline) and cytidine 5'-diphosphocholine is a psychostimulant/nootropic. It is an intermediate in the generation of phosphatidylcholine from choline. CDP-choline is a Nootropic compound that is essentially a prodrug for both Choline and Uridine, conferring both of those molecules to the body following oral ingestion of CDP-Choline. Specifically, the CDP-choline dissociates into choline and cytidine, with the cytidine then converting into uridine. CDP-choline is one of the three choline-containing phospholipids that can be orally supplemented (the other two being Alpha-GPC and Phosphatidylcholine).
This supplement is catered towards increasing memory. Both of the molecules it confers are neuroprotective and potentially enhance learning. While it appears to be more effective than phosphatidylcholine (PC) at this role, in part due to also increasing PC synthesis in the brain, its potency is somewhat comparable to that of Alpha-GPC. CDP Choline is one of the most effective cholinergics currently available and can be taken alone or in conjunction with a racetam.
Standard dosing of CDP-choline is to take 500-2,000 mg in two divided doses (of 250-1,000 mg) usually separated by 8-12 hours, although a single daily dose is also sometimes used. A single dose of 4,000 mg does not appear to affect the blood any differently than 2,000 mg, and so it is not necessary to take such a high dose. There are some properties, such as attention-promotion or improving bioenergetics, that seem to respond exclusively or more strongly to the lower dosage range. Other properties like appetite are the opposite, and thus the ideal dosage depends somewhat on the goal.
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