L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain. Alpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a cholinergic compound and a parasympathomimetic acetylcholine precursor which is used as a nootropic dietary supplement to enhance memory, cognition, and aids in preventing cognitive decline. It has also been noted to enhance potassium-invoked dopamine release from neurons, which is thought to be due to interactions at the cellular membrane.

Athletes are at times interested in it due to its ability to enhance growth hormone production (of which only acute spikes have been reported so far) and to enhance power output. Although traditionally known as being nonstimulatory, some people do report cognitive stimulation with supplemental alpha-GPC.

It is a choline-containing supplement that, although found in a variety of food products that are also rich in choline, appears to be pharmacologically active at higher doses. Commonly used doses are 300 to 1,200 mg daily, often divided into multiple doses and it may be prudent to take alpha-GPC alongside dietary fatty acids for absorption (due to it being a phospholipid), although this does not appear to be an absolute requirement. It is approximately 40% choline by weight, and as such 1,000 mg alpha-GPC confers about 400 mg of dietary choline.

Disclaimer: these statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease or illness. If you have any health conditions, please consult a physician before taking this or any other product. Discontinue use if you have any adverse reaction.

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Alpha GPC 99%

  • Product Code: Pure Powder
  • Availability: In Stock
  • $89.95


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